Preventing the maturation or intracellular trafficking of tyrosinase is an alternative way to reduce the effect of the enzyme on pigmentation.

Various natural extracts can also influence tyrosinase mRNA at the transcription level; also mRNA of the other tyrosinase-related proteins or microphtalmia transcription factor (MITF) can be affected. The protease activated receptor 2 (PAR-2) is important for melanosomal transfer from melanocytes to keratinocytes and that this transfer can be used as a target for skin lightening.

Regulation of cutaneous pigmentation is dependent on several processes beyond melanin synthesis within the melanosome. The efficiency of melanosomal transfer from melanocytes to keratinocytes, followed by melanosome processing in the recipient keratinocytes plays a critical role in skin pigmentation.

Without successful transfer of melanosomes to keratinocytes, the skin can appear essentially unpigmented.

Treatment modalities aimed at inhibiting melanosome transfer may influence and modulate skin pigmentation.