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aloesin

Aloesin molecule  

Aloesin, a natural hydroxymethyl chromone compound isolated from the aloe vera plant) with structure is rather similar to flavonols.

It has been proven to competitively inhibit tyrosinase from human, mushroom, and murine sources. Studies have shown that tyrosine hydroxylase and DOPA (3,4-dihydroxyphenylalanine) oxidase activities (of tyrosinase from normal human melanocyte cell lysates) are inhibited by aloesin in a dose-dependent manner. The topical application of aloesin on UV-irradiated (210 mJ) human volar forearm (four times a day for 15 days) showed pigmentation suppression in a dose-dependent manner.

The hydrophilic nature of the compound reduces the skin penetration of aloesin. Hence, combination treatment of aloesin with arbutin has been observed to synergistically inhibit melanin production by combined mechanisms of noncompetitive and competitive inhibitions of tyrosinase activity.

Testing of aloesin revealed no cytotoxicity, which makes it a good alternative to HQ.

 

 

 
 
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TOP 20
Hydroquinone
Monobenzyl Ether of Hydroquinone
Azelaic Acid
Kojic Acid
Arbutin
Retinoids
Mequinol
Niacinamide
Soy
Vitamin C
Corticosteroids
Licorice
Hydroxystilbene
Aloesin
Glutathione
Glycolic Acid
N Acetyl Glucosamine
Gentisic Acid
Green Tea
Melatonin

SKIN WHITENING AGENTS A-Z
a-Hydroxyacids
Aloesin
Alpha Tocopherol and Alpha Tocopherol Ferulate
Arbutin
Azelaic Acid
Centaureidin and Methylophiopogonanone B
Gallic Acid and Derivatives
Gingko
Ginseng
Glutathione
Glycolic Acid
Green Tea
Hesperidin
Hydroquinone
Hydroxycinnamic Acid and Derivatives
Hydroxystilbene
Kojic Acid
Licorice
Linoleic Acid
Magnesium Ascorbyl Phosphate
Melatonin
Mequinol
Monobenzyl Ether of Hydroquinone
Mulberry
N Acetyl Glucosamine
N-Acetyl-4-S-Cysteminylphenol
Niacinamide
Retinoids
Salicylic Acid
Soy
Vitamin C

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